Reconstruction of the tendon-bone junction with tubular titanium web:A miniature swine model study

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462352
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Jikei University School of Medicine
• Principal Investigator: MARUMO KEISHI 東京慈恵会医科大学, 医学部, 教授 (70199925)
• Co-Investigator(Kenkyū-buntansha): SAITO MITSURU 東京慈恵会医科大学, 医学部, 准教授 (50301528) ; KUROSAKA DAIZABURO 東京慈恵会医科大学, 医学部, 助教 (80297382)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: チタン再繊維 / 靱帯・骨接合部 / 再建靱帯 / ミニブタ

Outline of Final Research Achievements

Anterior cruciate ligament (ACL) reconstructions using autologous tendon tissue reinforced by tubular titanium web (TW) of titanium microfibers were performed in knee joints of miniature swine. At 4 and 15 weeks, tendon/ligament maturation in the reconstructed ACLs (r-ACL) was observed; this indicated that TW facilitates attachment of tendon/ligament and bone. Furthermore, maturation process of collagen, the main structural element of bony- and tendon-like tissue forming within the titanium web was not impaired and normal patterns of tissue-specific collagen cross-links were found within the tissue matrix. These findings confirm that TW is an effective material for reconstructions of tendon/ligament-bone junctions.

Free Research Field

医歯薬学