Mechanisms of bone fragility in patients with rheumatoid arthritis

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462357
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Hokkaido University
• Principal Investigator: Takahata Masahiko 北海道大学, 医学(系)研究科(研究院), 講師 (40374368)
• Co-Investigator(Kenkyū-buntansha): SUDA Hiromi (木村 廣美) 千歳科学技術大学, 理工学部, 教授 (00574857) ; TODO Msahiro 北海道大学, 大学院工学研究院, 准教授 (10314402) ; AMIDUKA Norio 北海道大学, 大学院歯学研究院, 教授 (30242431)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 骨粗鬆症 / 関節リウマチ / ステロイド / 骨質異常

Outline of Final Research Achievements

To elucidate the cause of increased fragility fracture risk in patients with rheumatoid arthritis (RA), we compared bone quality and quality between RA patients and age and sex-matched postmenopausal non-RA patients using bone biopsy samples. Despite that there was no significant difference in bone mineral density between two groups, bone strength and toughness were significantly lower in RA group than in non-RA group. Deterioration in bone quality including the degree of mineralization and bone microstructure found in RA patients most likely associated with decreased bone mechanical properties.

Free Research Field

整形外科学　骨代謝学