Contributing factors to periarticular osteoporosis in rheumatoid arthritis

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462368
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Kyoto University
• Principal Investigator: ITO Hiromu 京都大学, 医学(系)研究科(研究院), 准教授 (70397537)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 関節リウマチ / 傍関節性骨粗鬆 / ケモカイン / 機能障害 / 骨治癒

Outline of Final Research Achievements

In bone healing of the mouse femur, MCP-1, a chemokine, was expressed in the early phase, and its blockade delayed bone healing. These results indicate MCP-1 plays an important role in the early phase of bone healing.
Bone mineral density (BMD) of the distal end of the forearm in patients with rheumatoid arthritis (RA) was lower than that of the shaft of the forearm, and joint destruction of the hand and functional disability of the upper hand were independent predictors for lower BMD of the forearm. Therefore, juxtaarticular osteoporosis has strong impact in the joint destruction and function in patients with RA.

Free Research Field

整形外科学、リウマチ学