Investigation of the relationship between bone formation and inflammatory signaling

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462369
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Research Institute, Osaka Medical Center for Maternal and Child Health (2015); Osaka University (2013)
• Principal Investigator: Higuchi Chikahisa 地方独立行政法人大阪府立病院機構大阪府立母子保健総合医療センター(研究所), その他部局等, その他 (40432421)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: osteoblast / Btk / CRP / MEK5

Outline of Final Research Achievements

We investigated the relationship between inflammatory signaling and osteoblasts. Our data demonstrated that Bruton’s tyrosine kinase(Btk) and C reactive protein(CRP)/FcR signal pathways suppresseed the osteoblastic differentiation. In addition, mitogen-activated protein kinase (MAPK) kinase 5 (MEK5) also suppressed the osteoblastic differentiation.
The results in the present study suggested that small molecules to inhibit these signaling pathways might be candidate agents for the treatment of fracture or bone defect to accelerate bone formation.

Free Research Field

整形外科　骨代謝