Establishment of novel biologics against rheumatoid arthritis. -As a target of Wnt noncanonical pathway-

2016 Fiscal Year Final Research Report

• Project/Area Number: 25462385
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Jikei University School of Medicine
• Principal Investigator: MAEDA KAZUHIRO 東京慈恵会医科大学, 医学部, 助教 (50548849)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 破骨細胞 / 関節リウマチ / Ｗｎｔ

Outline of Final Research Achievements

I reported that Wnt5a enhances RANKL-induced osteoclastogenesis through noncanonical Wnt signaling which is the downstream of receptor tyrosine kinase Ror2, previously. Furthermore, we reported the possibility of the novel therapeutic target for rheumatoid arthritis by inhibiting it. In this study, we try to generate Ror2 inhibitor to inhibit Wnt noncanonical pathway.
To try to generate the neutralizing antibody, we collected Ror2 protein using Ror2 overexpressing CHO cells, but failed. 　Because of this, we search for the low molecular compounds for inhibition of Wnt noncanonical pathway. As a result we found that the compound which inhibits some transcriptional factor suppressed wnt5a-enhanced osteoclastogenesis.

Free Research Field

整形外科