2016 Fiscal Year Final Research Report
Investigation on the safety of anesthetic management for patients with psychotropic medication
Project/Area Number |
25462400
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Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Anesthesiology
|
Research Institution | University of Toyama |
Principal Investigator |
SASAKI RIKA 富山大学, 大学院医学薬学研究部(医学), 助教 (10345572)
|
Co-Investigator(Renkei-kenkyūsha) |
HIROTA KOKI 富山大学, 大学院医学薬学研究部(医学), 准教授 (30218854)
|
Project Period (FY) |
2013-04-01 – 2017-03-31
|
Keywords | 向精神薬 / 海馬 / シナプス伝達 |
Outline of Final Research Achievements |
In order to investigate modification of general anesthetic actions in the presence of psychotropic medications, we have studied the effects of general anesthetics on synaptic transmission in the absence or presence of psychotropic agents in the rat amygdalo-hippocampal slices. Our results indicated that psychotropic agent, valproic acid, modified the amygdala neural input and enhanced the attenuation of hippocampal synaptic transmission by general anesthetic, thiopental. In case of anesthetic managements of psychotropic medicated patients, anesthesiologists should pay attention to anesthetic depth because of destabilization of general anesthetic actions in the central nervous systems.
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Free Research Field |
麻酔科学
|