2016 Fiscal Year Final Research Report
General anesthesia and interaction of anesthetics.
| Project/Area Number |
25462402
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology
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| Research Institution | Nagoya University (2013, 2016)
Tokyo Medical and Dental University (2015) |
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Principal Investigator |
Adachi Yushi 名古屋大学, 医学系研究科, 准教授 (80420355)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 全身麻酔 / 相互作用 / 麻酔薬 / 就眠 |
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| Outline of Final Research Achievements |
We established the experimental procedures mainly using mice. The hypnotic endpoint was evaluated by a loss of righting reflex and a recovery of it. We obtained results that explain a part of the mechanism of action of general anesthetic through detailed analysis of interaction of various anesthetic agents. Especially, we examined the interaction between propofol and non-benzodiazepine hypnotics called as JM-1232(-), developed in Japan recently and found the new profile of general anesthesia by co-administration of both drugs. These achievements are announced at the international conference and are currently posting.
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| Free Research Field |
麻酔
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