2016 Fiscal Year Final Research Report
The study to clarify the excitatory effect of anesthetics on neuronal toxicity in the neonatal brain
| Project/Area Number |
25462408
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology
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| Research Institution | Yokohama City University |
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Principal Investigator |
ISHIWA Dai 横浜市立大学, 医学研究科, 客員准教授 (30457858)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 麻酔薬 / 幼若脳 / アポトーシス |
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| Outline of Final Research Achievements |
It has been reported that anesthtic agents induce apoptosis abundantly over the brain in the neonate but its mechanisims remain unknown.The GABAA stimulants induce neuronal depolarization and have excaitatory effects in cortex and hippocampus. Due to these effects, neurons may lead to neuronal death.
In this study we clarify neonatal administration of midazolam disrupt learning ability in the adolescent and this effect can be rescued by CLP290.
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| Free Research Field |
麻酔科学
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