Elucidation of the pathogenesis of brain white matter injury caused by perioperative hypoxic ischemia and the development of regeneration therapy

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462410
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology
• Research Institution: Nagoya City University
• Principal Investigator: KAKO Eisuke 名古屋市立大学, 医学(系)研究科(研究院), 研究員 (70464576)
• Co-Investigator(Kenkyū-buntansha): SASANO Hiroshi 名古屋市立大学, 大学院医学研究科, 教授 (20215742) ; SOBUE Kazuya 名古屋市立大学, 大学院医学研究科, 教授 (90264738)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 再生医療 / 白質傷害 / 小児 / 周術期

Outline of Final Research Achievements

Brain white matter injury in the perioperative period of childhood has a high frequency is no cure. First, we create a brain white matter injury model using a newborn mouse. The immature brain, oligodendrocyte progenitor cells (OPC) moved to the ischemic site by cerebral ischemia, but were found not to differentiate. Therefore, we adopted the asialo-erythropoietin (EPO) as a promoting factor of differentiation. In cultured cells and brain white matter injury model, differentiation from the OPC to oligodendrocytes has been promoted by the EPO. As a treatment for white matter injury by cerebral ischemia, the moving of endogenous OPC and promoting differentiation by and EPO has a possibility of clinical application.

Free Research Field

麻酔蘇生学