The study of shock states using microcirculation or coagulation as relevant indices

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462417
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology
• Research Institution: Tokyo Women's Medical University
• Principal Investigator: KOMORI MAKIKO 東京女子医科大学, 医学部, 教授 (60178332)
• Co-Investigator(Kenkyū-buntansha): NISHIYAMA Keiko 東京女子医科大学, 医学部, 准教授 (00155532) ; TOMIZAWA Yasuko 東京女子医科大学, 医学部, 助教 (00159047) ; KODAKA Mitsuharu 東京女子医科大学, 医学部, 臨床教授 (90280635) ; ICHIKAWA Junko 東京女子医科大学, 医学部, 講師 (60318144)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 微小循環 / ショック / 敗血症 / 大量出血

Outline of Final Research Achievements

In the fundamental research, microcirculation dynamics at shock states (hemorrhage, sepsis, anaphylaxis) was studied by microscopic observation using a rabbit ear chamber (REC). An arteriolar vascular diameter, a blood flow rate and motions of venular leukocyte in REC were directly recorded and analyzed during shock states. In the case of a hemorrhagic shock, we studied the effects of hydroxyethyl starch (HES) on the microcirculation and central venous oxygen saturation (ScvO2). After fluid infusion, the recovery of arteriolar diameter, blood flow velocity, and blood flow rate was significantly better in the HES group than in the normal saline group. ScvO2 after completing infusion was significantly greater in the HES group. In the clinical research, we observed nail bed microcirculation by intravital microscopy in ICU. The vessel diameter of the patient with the cardiac failure was significantly thinner, but the density of the blood vessel was higher than that of a normal person.

Free Research Field

医歯薬学