2015 Fiscal Year Final Research Report
Role of endogenous prostanoids in development of vascular remodeling
| Project/Area Number |
25462421
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Anesthesiology
|
|---|
| Research Institution | Asahikawa Medical College |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | 内因性プロスタノイド / 血管リモデリング / EP4受容体 |
|---|
| Outline of Final Research Achievements |
Vascular endothelial dysfunction induces inflammatory responses in the arterial walls and stimulates migration of smooth muscle cells (SMCs) from the media to the intima and subsequent proliferation of SMCs within the intima. These vascular responses are thought to be important processes for neointimal formation and vascular remodeling, resulting in narrowing of the vascular lumen. The purpose of the present study was to determine the role of EP4 receptor, which is one of endogenous PGE2 receptors, in vascular remodeling using a carotid artery ligation model. The pathological derangement in EP4 knock-out mice was larger than that in WT mice 7 days after ligation of carotid artery, however, these changes was disapperard 28 days after ligation of artery.
These data suggests that EP4 receptor would affect early phase of vascular remodeling.
|
| Free Research Field |
麻酔科学
|
