Effects of protective one-lung ventilation on respiratory and renal outcomes in patients undergoing esophagectomy

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462426
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Ishikawa Seiji 東京医科歯科大学, 医学部附属病院, 講師 (60282737)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 一側肺換気 / 保護的換気戦略 / 急性腎障害 / 食道切除術 / 食道癌 / バイオマーカー

Outline of Final Research Achievements

We have investigated the effects of different one-lung ventilation (OLV) strategy on the outcome variables in patients undergoing esophagectomy. After randomization, 13 and 18 patients were allocated in conventional OLV group and protective OLV group, respectively. No outcome variables including mortality rate, duration of hospital stay, duration of intensive care unit stay, and need for reintubation was significantly different between the groups. No renal biomarkers was found to be different between the groups. The present study may suggest that the effects of protective OLV on the outcome variables are minimal in patients undergoing esophagectomy.

Free Research Field

麻酔学