2015 Fiscal Year Final Research Report
The Shivering Threshold with various antiemetics in Rabbits.
| Project/Area Number |
25462428
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Anesthesiology
|
|---|
| Research Institution | University of Yamanashi |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
IWASHITA Hironobu 山梨大学, 総合研究部, 助教 (10232670)
MATSUKAWA Takashi 山梨大学, 総合研究部, 教授 (80209519)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | 体温 / シバリング / 制吐薬 |
|---|
| Outline of Final Research Achievements |
Perioperative hypothermia is common and causes numerous serious complications. On the other hand, since nausea and vomit often happens, there are a lot of chances to administrate antiemetic in perioperative period. Droperidol and Travelmin® are usually used as an antiemetic in perioperative period. Travelmin® is composed of diphenhydramine hydorochloride and diprophylline. We evaluated the effect of droperidol and Travelmin® on the shivering threshold in rabbits, since the shivering thresholds in rabbits have been researched in our laboratory for years.
High-dose droperidol significantly reduces the shivering threshold in rabbits. Droperidol should prevent or treat shivering after surgery or during induction of therapeutic hypothermia. Travelmin® did not change the shivering threshold in rabbits. We cannot expect Travelmin® as a suppressing agent of shivering.
|
| Free Research Field |
麻酔科学
|
