2015 Fiscal Year Final Research Report
Myocardial preconditioning effects of high-dose insulin and PI3K/Akt signaling pathway
| Project/Area Number |
25462429
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUKAWA Takashi 山梨大学, 総合研究部, 教授 (80209519)
ISHIYAMA Tadahiko 山梨大学, 医学部附属病院, 准教授 (90293448)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | インスリン / プレコンディショニング |
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| Outline of Final Research Achievements |
Acute hyperglycemia diminishes the cardioprotection induced by ischemic preconditioning in the isolated rat heart. The current study showed that acute hyperglycemia reduced the p-Akt level, in spite of insulin administration prior to the ischemic period. Inhibition of myocardial Akt phosphorylation is a possible mechanism by which hyperglycemia attenuates the cardioprotective effect of insulin. Normalizing blood glucose before ischemia is important to maximize insulin-induced cardioprotection in stunned rat heart.
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| Free Research Field |
麻酔科学
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