Effect of anesthetics on sepsis-induced cerebral inflammatory cytokine upregulagtion

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462432
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology
• Research Institution: Kyoto University
• Principal Investigator: Tanaka Tomoharu 京都大学, 医学(系)研究科(研究院), 助教 (10402893)
• Co-Investigator(Renkei-kenkyūsha): HIROTA Kiichi 関西医科大学, 医学部, 准教授 (00283606)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: マイクログリア / IL-1b / 麻酔薬

Outline of Final Research Achievements

General anesthetics including isoflurane and propofol time-and dose-dependently suppressed inflammatory cytokine, especially IL-1b, upregulation induced by LPS in microglia cell line. Both anesthetics significantly suppressed the phosphorylation of MAPK, and the result suggested that the effect of anesthetics on MAPK is the essential mechanism of cytokine suppression. In the experiment adopting sepsis model mice, isoflurane significantly suppressed IL-1b induction in brain, and decreased ACTH concentration in blood. Those results suggested that general anesthetics affect the sepsis-induced IL-1b induction in brain, and may have a great impact on stress response using hypothalamus-adrenal gland axis.

Free Research Field

麻酔科学