Gene Therapy for Chronic pain by modulating the SNPs of pacemaker ion channels.

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462436
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology
• Research Institution: Okayama University
• Principal Investigator: Ryuji Kaku 岡山大学, 医歯(薬)学総合研究科, 助教 (50444659)
• Co-Investigator(Kenkyū-buntansha): OBATA Norihiko 神戸大学, 医学部附属病院, 助教 (30509443)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 慢性痛 / 遺伝子治療 / ペースメーカーチャンネル

Outline of Final Research Achievements

The pace maker ion channels play a major role on regulating the neuropathic pain, especially it work as modulator at the shift state from acute pain to chronic pain. It is also reported that the SNPs of that ion channels do not pass the current, but it exist on the cell surface. We investigated that cyclic AMP can reduce the expression that ion channels to the cell membrane, and it also can decrease the pain behavior of rat spinal nerve ligation (SNL) model. It suggests that over expression of SNPs ion channels can reduce the pain current, and may inhibit the shift from acute pain to chronic pain.

Free Research Field

痛みの遺伝子治療