Effects of the glucagon-like peptide-1 receptor agonist on the functional recovery of myocardial stunning in pigs.

2016 Fiscal Year Final Research Report

• Project/Area Number: 25462441
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology
• Research Institution: Nagasaki University
• Principal Investigator: SHIBATA Itsuko 長崎大学, 病院(医学系), 助教 (10404245)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 心筋虚血再灌流障害 / 心筋スタニング / GLP-1アナログ / 糖尿病治療薬

Outline of Final Research Achievements

We assessed the effect of liraglutude treatment of the stunned myocardium in anesthetized open chest swine. Administration of the Glucagon-like peptide-1 (GLP-1) analog liraglutide daily hypodermic injections 1 week or 1 day before ischemia protects the stunned myocardium in anesthetized open-chest swine. This cardioprotective effect of liraglutude against myocardial stunning was probably not related to systemic or coronary hemodynamic changes. Administration of GLP-1 analog liraglutide before ischemia protects against myocardial stunning.

Free Research Field

麻酔・蘇生学