2015 Fiscal Year Final Research Report
Identification of micro RNA involved in organ protective effects of general anesthetics.
| Project/Area Number |
25462459
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
CHIBA YOSHIHIKO 星薬科大学, 薬学部, 准教授 (00287848)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 麻酔薬 / 臓器保護 / マイクロRNA / 周術期管理 |
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| Outline of Final Research Achievements |
It has been reported that anesthetics used during surgery have protective effects on organs. However, the mechanism of organ protective effects of anesthetics is still unclear. The aim of our study was identification of micro RNA (miRNA) relating to this organ protective effects of anesthetics. We tried to identify miRNA involved in organ injury using rat renal ischemia-reperfusion injury model. With microarray analysis and real-time PCR, we found that SLC7A1 and RhoA are involved in ischemia-reperfusion injury in rat kidney.
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| Free Research Field |
麻酔科学
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