2016 Fiscal Year Final Research Report
Circadian variation of serum hormone concentration in relation with serum melatonin level and tissue clock gene expression in patients receiving prostate needle biopsy
| Project/Area Number |
25462468
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Gunma University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | ホルモン / 日内変動 / 前立腺 |
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| Outline of Final Research Achievements |
Serum hormone concentrations in adult males vary in a circadian manner. This study aimed to clarify the relationship between circadian variation of serum hormones and prostate disease in patients under well-controlled conditions who are hospitalized for undergoing a prostate needle biopsy. This study included 109 patients undergoing prostate biopsy. Blood samples were collected for hormone determination twice in morning and afternoon.
Serum DHEA-S concentration in the morning was lower in prostate cancer than non-cancer patients. The variation of melatonin was smaller in prostate cancer than non-cancer patients. Clock genes PER2 and CLK were well expressed in the needle biopsy specimen, but there were no significant relation with prostate diseases.
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| Free Research Field |
泌尿器科学
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