Analysis for glycolysis-related genes as potential therapeutic targets in clear cell renal cell carcinoma

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462480
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Yamaguchi University
• Principal Investigator: NAGAO Kazuhiro 山口大学, 医学部附属病院, 講師 (70379949)
• Co-Investigator(Kenkyū-buntansha): MATSUMOTO Hiroaki 山口大学, 医学部附属病院, 助教 (60610673) ; MATSUYAMA Hideyasu 山口大学, 大学院医学系研究科, 教授 (70209667) ; IKEDA Eiji 山口大学, 大学院医学系研究科, 教授 (30232177)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: FABP / renal cell carcinoma / therapeutic target / marker

Outline of Final Research Achievements

To identify potential targets in clear cell renal cell carcinoma (ccRCC), we performed an experiment to confirm the significance of FABP7 as a potential target and marker in ccRCC. Our immunohistochemical analysis showed that higher FABP7 expression was significantly correlated with distant metastasis and poor cancer-specific survival in ccRCC. Functional suppression of FABP7 resulted in significant growth inhibition and significant reduction of the invasive potential of a ccRCC cell line. Functional suppression of FABP6 resulted in significant growth inhibition and significant reduction of the invasive potential of another ccRCC cell line.
FABP7 and 6 could be a potential therapeutic target and diagnostic marker in metastatic ccRCC.

Free Research Field

泌尿器科学