Interaction between urothelial carcinoma and adipose tissue in survival, proliferation, migration, invation

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462485
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Saga University
• Principal Investigator: Jiro Uozumi 佐賀大学, 医学部, 客員研究員 (30223514)
• Co-Investigator(Kenkyū-buntansha): TODA SHUJI 佐賀大学, 医学部, 教授 (80188755) ; TOKUDA YUJI 佐賀大学, 医学部, 客員研究員 (90315200) ; NOGUCHI MITSURU 佐賀大学, 医学部, 教授 (00325648)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 表在性膀胱癌 / 浸潤性膀胱癌 / 脂肪組織 / 癌ー間質相互作用 / MAPKK / MMP / COX-2 / HER-2

Outline of Final Research Achievements

The adipose tissue stromal cells (ATSCs) suppress the progression of superficial urothelial carcinoma through their growth inhibition and apoptosis promotion, whereas ATSCs promote that of the invasive urothelial carcinoma through the enhancement of the growth and invasion, and the apoptosis prohibition. ATSCs had no effect on the invasion of superficial types, whereas they promoted the invasion of invasive types. ATSCs promoted the expression of mitogen-activated protein kinase (MAPK) in all cancer cell types. Superficial type could not invade into gel with ATSC, which promoted invasion and MAPK molecules. ATSC-induced MAPK pathway activation plays differential roles in biological behavior of superficial and invasive types. MMP-2, MMP-7 and MMP-9 are critical for the invasion of invasive type under cancer-stromal interaction.

Free Research Field

泌尿器科