Chemoprevention of prostate cancer using inhibition of PGE2 receptors and HuR suppression by green tea polyphenol

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462488
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Nagasaki University
• Principal Investigator: SAKAI Hideki 長崎大学, 医歯薬学総合研究科(医学系), 教授 (40235122)
• Co-Investigator(Kenkyū-buntansha): MIYATA Yasuyoshi 長崎大学, 医歯薬学総合研究科(医学系), 准教授 (60380888) ; OHBA Kojiro 長崎大学, 病院(医学系), 講師 (20593825)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 前立腺癌 / E prostanoid receptor / human antigen R / cyclooxygenase-2 / prostaglandin E2

Outline of Final Research Achievements

Limited information is available on the pathological significance of human antigen R (HuR) in prostate cancer. We studied the relationship between HuR expression and malignant aggressiveness, and expression of cancer-related molecules in prostate cancer. Our results demonstrated that HuR plays important roles in determining malignant aggressiveness and outcome in prostate cancer, via the regulation of cell proliferation, migration, and expression of VEGF-A, -C, and COX-2. The suppression of HuR might be useful for prevention of prostate cancer.

Free Research Field

泌尿器科学