2015 Fiscal Year Final Research Report
The glycoprotein carrying sialyl T as a possible marker for renal cell carcinoma
Project/Area Number |
25462491
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Urology
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Research Institution | University of the Ryukyus |
Principal Investigator |
SAITO Seiichi 琉球大学, 医学(系)研究科(研究院), 教授 (80235043)
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Co-Investigator(Kenkyū-buntansha) |
GOYA Masato 琉球大学, 医学部附属病院, 講師 (50295317)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Keywords | 腎細胞癌 / 血清マーカー / 糖鎖 |
Outline of Final Research Achievements |
GP-RCC, which has been identified in the process of searching the glycoprotein carrying sialyl T antigen, decreased in the patients with clear cell renal cell carcinoma (RCC). Serum level of GP-RCC was significantly lower in 63 patients with clear cell RCC than in 53 having benign urologic diseases without RCC (p=0.0004). Increase of serum GP-RCC level was confirmed after radical nephrectomy for clear cell RCC in five out of six patients. Molecular size (45kDa) of serum GP-RCC was larger than that (38kDa) extracted from RCC cell lines. Molecular size was decreased by glycosidase treatment of serum GP-RCC, suggesting serum GP-RCC is heavily glycolsylated compared to GP-RCC existing in RCC cell lines. From the results, it was indicated that a decrease of GP-RCC was a new marker for clear cell RCC.
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Free Research Field |
泌尿器系癌
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