The glycoprotein carrying sialyl T as a possible marker for renal cell carcinoma

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462491
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: University of the Ryukyus
• Principal Investigator: SAITO Seiichi 琉球大学, 医学(系)研究科(研究院), 教授 (80235043)
• Co-Investigator(Kenkyū-buntansha): GOYA Masato 琉球大学, 医学部附属病院, 講師 (50295317)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 腎細胞癌 / 血清マーカー / 糖鎖

Outline of Final Research Achievements

GP-RCC, which has been identified in the process of searching the glycoprotein carrying sialyl T antigen, decreased in the patients with clear cell renal cell carcinoma (RCC). Serum level of GP-RCC was significantly lower in 63 patients with clear cell RCC than in 53 having benign urologic diseases without RCC (p=0.0004). Increase of serum GP-RCC level was confirmed after radical nephrectomy for clear cell RCC in five out of six patients. Molecular size (45kDa) of serum GP-RCC was larger than that (38kDa) extracted from RCC cell lines. Molecular size was decreased by glycosidase treatment of serum GP-RCC, suggesting serum GP-RCC is heavily glycolsylated compared to GP-RCC existing in RCC cell lines. From the results, it was indicated that a decrease of GP-RCC was a new marker for clear cell RCC.

Free Research Field

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