Analysis of Angiotensin 1-7 to modulate androgen receptor expression in prostate cancer cells

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462493
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Yokohama City University
• Principal Investigator: Uemura Hiroji 横浜市立大学, 附属市民総合医療センター, 教授 (50244439)
• Co-Investigator(Kenkyū-buntansha): Kubota Yoshinobu 横浜市立大学, 学長 (10106312)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 前立腺癌 / レニンーアンジオテンシン系 / アンジオテンシン1-7

Outline of Final Research Achievements

We have reported that renin-angiotensin system is involved in the development and progression of prostate cancer. Angiotensin II (AngII) receptor blocker was proven to have the potential of antitumor effect that was demonstrated by experimental and clinical investigation. This study showed that Angiotensin 1-7 (Ang1-7) which is converted from AngII by angiotensin converting enzyme 2 may have also antitumor effect for prostate cancer. We performed the experiment that demonstrated Ang1-7 may influence androgen receptor in prostate cancer cells.

Free Research Field

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