Examination of the growth depression effect of bladder tumor through the multinucleated cell formation by the polyethylene glycol

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462497
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Nagoya City University
• Principal Investigator: Fukuta Katsuhiro 名古屋市立大学, 医学(系)研究科(研究院), 研究員 (30468251)
• Co-Investigator(Kenkyū-buntansha): KAWAI Noriyasu 名古屋市立大学, 大学院医学研究科, 講師 (20254279) ; KOHRI Kenjiro 名古屋市立大学, 学長 (30122047) ; TOZAWA Keiichi 名古屋市立大学, 大学院医学研究科, 准教授 (40264733) ; NAIKI Taku 名古屋市立大学, 大学院医学研究科, 助教 (50551272)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: polyethylene glycol / 多角巨細胞 / アポトーシス / 前立腺癌 / 膀胱癌 / 腺癌 / 尿路上皮癌

Outline of Final Research Achievements

The background of the study is based on PEG has the feature as a chemotherapeuatic agent through the induction of multinucleated cell formation and apotosis induction in PC-3 prostate cancer cells. The aim of this study is to evaluate this effect of PEG for bladder cancer cells. However, in this study using the bladder cancer cell line, the expected results were not indicated. The bladder cancer was "urothelial cancer" histologically. The bladder cancer was thought to be different from prostate cancer which was "adenocarcinoma" histologically in a property. In the study using the human gastric cancer cells “NCI-N87” which were "adenocarcinoma", PEG suggested the effort of itself for “NCI-N87” cancer cells. We could not perform in vivo study in this study period. We are going to examine effects of the PEG by the cytological difference for "adenocarcinoma" "urothelial carcinoma" in future.　By the results, we identify the carcinoma with responsibility.

Free Research Field

泌尿器腫瘍学