2015 Fiscal Year Final Research Report
The study of Endogenous vaccine effect by high-precision radiation therapy
| Project/Area Number |
25462500
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Kitasato University |
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Principal Investigator |
KUBO Makoto 北里大学, 医療衛生学部, 講師 (40464804)
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| Co-Investigator(Kenkyū-buntansha) |
SATOH Takefumi 北里大学, 医学部, 准教授 (50286332)
ISHIYAMA Hiromichi 北里大学, 医学部, 講師 (60343076)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 前立腺癌 / 放射線治療 / Endogenousワクチン |
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| Outline of Final Research Achievements |
Radiation therapy (RT) is one of the most important treatments for prostate cancer. Patients treated by RT were occasionally observed that metastatic cancer without directly radiation disappeared after RT treatment. RT might be able to induce effectively anti-tumor immunity. However, the details of immune responses were not clear in RT. Then, the lymphocyte subsets were analyzed by flow cytometry. The proportion of activated T cells in peripheral blood gradually increased after one of the RT treatment (low-dose-rate brachytherapy). RT treatment indicates to be inducible immune responses.
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| Free Research Field |
免疫学
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