Surveillance of antimicrobial susceptibility of pathogens of male urethritis

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462509
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Gifu University
• Principal Investigator: Deguchi Takaashi 岐阜大学, 医学(系)研究科(研究院), 教授 (40163935)
• Co-Investigator(Kenkyū-buntansha): YSUDA Mitsuru 岐阜大学, 医学部附属病院, 講師 (90311703)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: Neisseria gonorrhoeae / Mycoplasma genitalium / 薬剤耐性 / 性感染症 / 尿道炎

Outline of Final Research Achievements

We examined clinical isolates of Neisseria gonorrhoeae for antimicrobial susceptibility and Mycoplasma genitalium DNAs for macrolide and quinolone resistance-associated mutations. We observed some isolates with decreased susceptibility to cefixime, with resistance to levofloxacin, and with resistance to azithromycin. We isolated a strain (GU140106) with decreased to ceftriaxone in 2014 but found that all other isolates were susceptible to ceftriaxone. We detected macrolide resistance-associated and/or quinolone resistance-associated mutations in M. genitalium DNAs. The presence of M. genitalium DNAs harboring both mutations suggested that some strains of M. genitalium might be evolving into multi-drug resistant ones. We should continue to pay attention to the antimicrobial susceptibility of these pathogens.

Free Research Field

感染症学