Research for urinary tract infection-causative carbapemase-producing bacteria

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462512
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Kobe University
• Principal Investigator: Shigemura Katsumi 神戸大学, 医学(系)研究科(研究院), 病院講師 (00457102)
• Co-Investigator(Kenkyū-buntansha): ARAKAWA Soichi 神戸大学, 大学院医学研究科腎泌尿器科学分野, 特命教授 (70159490) ; TANAKA Kazushi 神戸大学, 大学院医学研究科腎泌尿器科学分野, 特命教授 (20335433)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 尿路感染症

Outline of Final Research Achievements

Production of metallo-beta-lactamase (MBL) which is known as a class B carbapenemase-producing bacteria were investigated and MBL occupied 84.6 % in all CRE strains. All the bacteria were categorized as IMP-6 by sequencing. As to the bacteria other than Enterobacteriaceae, MBL producing bacteria occupied 76.4% in all the carbapenem-resistant Pseudomonas aeruginosa and sequencing data showed that IMP type was in 85.7%（IMP-1 type: 55.6% and IMP-7 type: 44.4%）and VIM type was 9.5%. Regarding epidemiological analysis, repetitive extragenic palindromic sequence (rep)-PCR data showed that 72 strains of extended-spectrum β-lactamases (ESBLs) producing Escherichia coli were categorized into 18 groups. The reproducibility of this method using ESBL producing strains may lead to further application for carbapenemase-producing bacteria.

Free Research Field

腎泌尿器科学