Functional analysis of urinary stone formation to target the mitochondrial membrane and its application to prophylaxis

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462520
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Nagoya City University
• Principal Investigator: Endo Sumio 名古屋市立大学, 医学(系)研究科(研究院), 研究員 (30646823)
• Co-Investigator(Kenkyū-buntansha): Kohri Kenjiro 名古屋市立大学, 学長 (30122047) ; Yasui Takahiro 名古屋市立大学, 大学院医学研究科, 教授 (40326153) ; Okada Atsushi 名古屋市立大学, 大学院医学研究科, 講師 (70444966) ; Niimi Kazuhiro 名古屋市立大学, 大学院医学研究科, 研究員 (70551274)
• Research Collaborator: Ito Yasuhiko 名古屋市立大学, 大学院医学研究科, 研究員
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 尿路結石 / cyclophilin D / ミトコンドリア / 酸化ストレス

Outline of Final Research Achievements

In this study by using the cyclophilin D deficient mice, we elucidate the effect of cyclophilin D to the formation of urinary tract stones in initial step at the molecular level, and aimed at the development of a prophylactic agent of urinary tract stones by inactivation of cyclophilin D.
When the oxidative stress such as oxalic acid stimulation applies to renal tubular cells, cyclophilin D is active and mitochondria collapse. This promotes oxidative stress and formation of urinary tract stone, we elucidat. So we prove inactivation of cyclophilin D suppress urinary stone formation. We think that it is a study that leads to the development of preventive medicine of the urinary stone.

Free Research Field

尿路結石