Prevention of urolithiasis using anti-NF-kB drugs

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462524
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Nagoya City University
• Principal Investigator: Tozawa Keiichi 名古屋市立大学, 医学(系)研究科(研究院), 准教授 (40264733)
• Co-Investigator(Kenkyū-buntansha): KOHRI Kenjiro 名古屋市立大学, 学長 (30122047) ; HAYASHI Yutaro 名古屋市立大学, 大学院医学研究科, 准教授 (40238134) ; HIROSE Yasuhiko 名古屋市立大学, 大学院医学研究科, 研究員 (60381894) ; OKADA Atsushi 名古屋市立大学, 大学院医学研究科, 講師 (70444966)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 尿路結石 / メタボリックシンドローム / 酸化ストレス / NF-kB / クルクミン

Outline of Final Research Achievements

Kidney stone formation has been recognized as a metabolic syndrome (MetS)-related disease. The aims of the present study were to elucidate a possible mechanism of kidney stone formation under MetS conditions by using MetS mouse model and to assess the effectiveness of curcumin treatment for the prevention of kidney stone. Wild-type (+/+) and ob/ob mice (having a disorder in which to produce leptin) were administered daily doses of 50 mg/kg glyoxylate (GOx) for 6 days. To prevent kidney stone formation, exogenous curcumin treatment (2%) was administered daily. At day 3, 7 and 14, their kidneys were extracted.
Curcumin inhibited NF-kB activation, oxidative stress and CaOX deposition in renal tubular cells. this study showed that curcumin treatment prevented kidney stone formation by inhibition of NF-kB activation, inflammation and apoptosis.

Free Research Field

尿路結石症