2015 Fiscal Year Final Research Report
Control of the micturition by the satellite glial cells of the dorsal root ganglion neurons innervating the urinary bladder
| Project/Area Number |
25462526
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Kwansei Gakuin University (2015)
Nara Medical University (2013) |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
Sato Hidetoshi 関西学院大学, 理工学部, 教授 (10300873)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 排尿障害 / 知覚神経 / 神経膠細胞 |
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| Outline of Final Research Achievements |
Expression of pleiotrophin (Ptn) protein was detected only in the glial satellite cells in the normal rat dorsal root ganglion (DRG) as like expression of mRNA. In addition, expression of Ptn protein in the cystitis model L6 DRG containing the neural cell bodies innervating urinary bladder was also shown mainly in the glial cells. Moreover, expression level of Ptn protein in L6 DRG containing the neurons innervating urinary bladder was increased by the bladder cystitis although expression level in L4 DRG unconnected the urinary bladder was stayed low. As a consequence, pleiotrophin might control to micturition and might be new therapeutic target for the voiding dysfunction.
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| Free Research Field |
排尿生理学
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