2015 Fiscal Year Final Research Report
Role of protein Z that is one of urinary stone matrix proteins in the progress of arteriosclerosis
| Project/Area Number |
25462528
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Teikyo University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
YAMAOKA Noriko 帝京大学, 薬学部, 准教授 (90582859)
FUKUUCHI Tomoko 帝京大学, 薬学部, 助教 (10389116)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | プロテインZ / 尿路結石症 / マトリックスタンパク質 / シュウ酸カルシウム結晶 |
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| Outline of Final Research Achievements |
A thrombus and arteriosclerosis are the severe clinical condition of the life. We analyzed urinary stones in detail, and confirmed that protein Z which suppresses blood clotting was included in a high frequency in the urinary stone and examined its role in the formation of urinary calculus. As a result, protein Z was detected in urinary stones that was composed of calcium oxalate monohydrate and it was found that protein Z made crystal of calcium oxalate monohydrate increase on the lipid membrane. Protein Z is expected to suppress blood clotting, but it is considered that protein Z has different role on generation of urinary calculus.
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| Free Research Field |
分析化学
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