2015 Fiscal Year Final Research Report
Suppression of antibody-mediated rejction by immunoglobulin G resulting from Fc sialylation
| Project/Area Number |
25462536
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
|
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| Research Institution | Tokyo Women's Medical University (2015)
Osaka University (2013) |
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Principal Investigator |
|
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| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | 腎移植 / 抗体関連型拒絶反応 / 免疫グロブリン |
|---|
| Outline of Final Research Achievements |
2g/kg Intravenous immunoglobulin (IVIg) treatment significantly suppressed inflammation and C4d deposition in kidney allografts in a rat antibody-mediated rejection kidney transplant model. This mechanism acts, not only to reduce expression of mRNA levels of C1q and C3 in kidney allografts, but to suppress production of donor specific antibody.
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| Free Research Field |
医歯薬学
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