2015 Fiscal Year Final Research Report
BK viral infection in Japanese kidney transplant patients
| Project/Area Number |
25462540
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KITADA HIDEHISA 九州大学, 大学病院, 助教 (10403958)
TSURUYA KAZUHIKO 九州大学, 医学研究院, 准教授 (20372740)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | BKウイルス / 腎移植 / 免疫抑制療法 / スクリーニング |
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| Outline of Final Research Achievements |
Polyomavirus BK nephropathy (BKVN) is an important complication in kidney transplant (KT) patients. Graft survival is extremely lower in the patient with BKVN. Those data were published from US and European countries and there is almost no data in Japanese KT patients. Thus we planned to investigate the incidence and severity of BK viral infection in Japanese patients via prospective, regular screening with polymerase chain reaction for BK viral DNA. A total of 62 living-donor KT patients received regular screening in urine and plasma. We found 14 patients who developed BK viruria, but no patient developed viremia or nephropathy. BK viruria was spontaneously disappeared in 8 patients, and 6 patients showed sustained viruria with low BK viral load. Those finding suggested that Japanese KT patients show low incidence of BK viral reactivation and the reactivation is mild under current immunosuppressive regimens.
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| Free Research Field |
泌尿器科学
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