2015 Fiscal Year Final Research Report
Analysis of human azoospermia and POF and its clinical advance
Project/Area Number |
25462547
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Obstetrics and gynecology
|
Research Institution | Asahikawa Medical College |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
SENGOKU Kazuo 旭川医科大学, 医学部, 教授 (30163124)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Keywords | azoospermia / SCOS / meiosis / mutation |
Outline of Final Research Achievements |
PLK-4 is a key regulator of centriole duplication and male mice with a point mutation in Plk4 are known to show azoospermia associated with germ cell loss. We found a heterozygous 13-bp deletion of PLK4 in an azoospermic patient with Sertoli cell-only syndrome (SCOS). In vitro centriole amplification was observed in wild-type PLK4-transfected cells, but not in mutant ones, indicating that the PLK4 mutation can cause azoospermia by SCOS.
|
Free Research Field |
male infertility
|