To establish a model of placental dysplasia using nanomaterials

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462555
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Osaka University
• Principal Investigator: Mimura Kazuya 大阪大学, 医学(系)研究科(研究院), 助教 (50437422)
• Co-Investigator(Kenkyū-buntansha): KANAGAWA TAKESHI 大阪大学, 医学系研究科, 招へい准教授 (40346218)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 胎盤形成 / ナノマテリアル / 酸化ストレス / 妊娠高血圧症候群

Outline of Final Research Achievements

We focused on pathogenesis in placental formation, studying the effect on pregnancy-induced hypertension (PIH) and fetal growth restriction (FGR) and preterm birth. We examined oxidative stress by nanomaterials, and the effects on migration and invasion as an in vitro study. As an in vivo study, we created a hypoplastic placental model by administering nanomaterials into pregnant mice, and examined the onset of PIH and FGR. In addition, as preterm birth model progesterone and nanomaterial hydroxide Fullerene suppressed the inflammatory reaction caused by ureaplasma TLR2 dependent system. We expected effective treatment for preterm birth in mice.

Free Research Field

妊娠高血圧症候群