In vivo functional analysis of cell fusion suppressor : Suppressyn

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462567
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: University of the Ryukyus
• Principal Investigator: Sugimoto Jun 琉球大学, 医学(系)研究科(研究院), 助教 (10315476)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: サプレシン / 細胞融合抑制 / 絨毛初代培養細胞 / 内在性レトロウイルス / 胎盤 / シンシチン

Outline of Final Research Achievements

Suppressyn is one of the first human proteins to be identified that inhibits cell-cell fusion. We have developed an efficient method for isolation and culture of primary trophoblast cells that allows the study of suppressyn ex vivo. In addition, murine placenta RNAseq expression analysis was used to identify potential mouse suppressyn equivalents. Expression of the four candidate transcripts was confirmed in murine placentas, and functional analysis of these is currently in progress. Our results may help to better define an in vivo role for suppressyn in normal human placental development.

Free Research Field

分子生物学