Fetal chromosomal abnormalities and early pregnancy loss in fetus-maternal translation

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462571
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Nagoya City University
• Principal Investigator: Suzumori Nobuhiro 名古屋市立大学, 医学(系)研究科(研究院), 准教授 (70326148)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 染色体 / 流産 / 遺伝子多型 / 出生前検査 / リスク因子 / メンタルストレス / 高齢妊娠 / 不育症

Outline of Final Research Achievements

As for embryonic factors, the frequency of normal embryonic karyotypes significantly increases with the number of previous abortions and a normal karyotype in a previous pregnancy is a predictor of subsequent miscarriage Although a currently prevailing hypothesis is that recurrent miscarriage may be a polygenetic disorder associated with both genetic and environmental determinants, it may be possible that the condition develops as a single-gene disorder. We found that the c.657T>C mutation of human SYCP3 gene may not be associated with recurrent miscarriage in Japanese. The FXII gene was found to be one of the significant susceptibility genes for miscarriage. However, the clinical influence of the FXII CT genotype or Protein S deficiency/Tokushima mutation data might be relatively small, because the presence/absence of this genotype did not have any predictive value for the subsequent pregnancy outcome.

Free Research Field

生殖遺伝学