2015 Fiscal Year Final Research Report
The relationship between endometrial stem cells and epithelial-mesenchymal transfer on the development of endometriosis.
| Project/Area Number |
25462574
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MARUYAMA Tetsuo 慶應義塾大学, 医学部, 准教授 (10209702)
UCHIDA Hiroshi 慶應義塾大学, 医学部, 専任講師 (90286534)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 子宮内膜症 / 子宮内膜幹細胞 / 上皮間葉転換（EMT） / Side Population / W5C5 |
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| Outline of Final Research Achievements |
Flow cytometry analysis revealed that endometrial side population (SP) cells, CD146+PDGFRβ+ cells and W5C5+ cells were different populations, but these populations overlapped partially. The migration activity of endometrial cells and endometrial SP cells was demonstrated, and the activity was suppressed by an epithelial-mesenchymal transfer inhibitor. We are trying to show this inhibitory effect in vivo using our mouse model.
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| Free Research Field |
生殖内分泌
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