2016 Fiscal Year Final Research Report
Identification of novel growth factors for ealy follicle growth and their clinical application
| Project/Area Number |
25462579
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | St. Marianna University School of Medicine |
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Principal Investigator |
Kawamura Nanami 聖マリアンナ医科大学, 医学部, 研究技術員 (70323152)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | 早発卵巣不全 / 卵胞発育 |
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| Outline of Final Research Achievements |
In this study, we sought to develop novel methods for ovarian follicle stimulation by identifying local factors important for early follicle growth and subsequent analyses of its molecular mechanisms. Based on comprehensive DNA microarray analyses, we determined the candidates of ligand/receptor pairs expressing in early stage of ovarian follicles and addressed their roles in follicle growth using murine in vitro and in vivo experiments. Among the candidates, we found C-type natriuretic peptide and CCN growth factor as factors for growth of secondary follicles onward, whereas R-spondin2 as a factor for growth of primary follicles onward.
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| Free Research Field |
生殖医学
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