2015 Fiscal Year Final Research Report
Bioinformatic analysis and functional genomics of refractory endometrial cancer subtype
| Project/Area Number |
25462589
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kyoto University |
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Principal Investigator |
Baba Tsukasa 京都大学, 医学(系)研究科(研究院), 講師 (60508240)
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| Co-Investigator(Kenkyū-buntansha) |
Konishi Ikuo 京都大学大学院医学研究科, 器官外科学・婦人科学産科学, 教授 (90192062)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 子宮体癌 / 漿液癌 / ドライバー |
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| Outline of Final Research Achievements |
Through bioinformatic analysis and functional genomics of refractory endometrial cancer subtypes, STAT1 pathway in serous carcinoma as well as GPR54-metastin axis in low grade endometrioid adenocarcinoma were detected as key molecules of tumor progression and new potent therapeutic targets. Based on these findings, development of molecular targeting therapy are in preparation as several international cooperative researches.
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| Free Research Field |
婦人科腫瘍学
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