Investigation of a new drug based on DNA mutation analysis in ovarian cancer.

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462590
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Kyoto University
• Principal Investigator: Matsumura Noriomi 京都大学, 医学(系)研究科(研究院), 准教授 (20452336)
• Co-Investigator(Kenkyū-buntansha): Konishi Ikuo 京都大学医学研究科器官外科学, 婦人科学産科学, 名誉教授 (90192062) ; Mori Seiichi 公益財団法人がん研究会, 研究員 (10334814)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 卵巣癌 / 遺伝子異常 / バイオマーカー

Outline of Final Research Achievements

We conducted a research about high-grade serous ovarian carcinoma (HGSOC), poor prognostic histopathological subtype of ovarian carcinoma. We established a novel histopathological classification that correlates with the four gene expression subtypes and taxane sensitivity of HGSOC. This result may identify a biomarker to select a taxane-containing chemotherapeutic regimen in HGSOC.

Free Research Field

婦人科腫瘍