Investigation of new treatment strategy for uterine carcinosarcoma by using cancer tissue originated spheroid

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462591
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Osaka University
• Principal Investigator: FUJITA MASAMI 大阪大学, 医学(系)研究科(研究院), 招へい准教授 (60303963)
• Co-Investigator(Kenkyū-buntansha): Yoshino Kiyoshi 大阪大学, 大学院医学系研究科, 准教授 (90362730) ; Ueda Yutaka 大阪大学, 大学院医学系研究科, 助教 (10346215) ; Kobayashi Eiji 大阪大学, 大学院医学系研究科, 助教 (50614773) ; Kimura Toshihiro 大阪大学, 大学院医学系研究科, 招へい教員 (90584524)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 婦人科腫瘍 / 子宮体部癌内腫

Outline of Final Research Achievements

Advanced uterine carcinosarcoma is difficult to cure and the standard treatment is not determined. We searched if we can establish primary culture of uterine carcinosarcoma by cancer tissue-originated spheroid (CTOS) method and if we can use drug screening kit for uterine carcinosarcoma by using CTOS method. One of the results is that we established primary culture of uterine carcinosarcoma by CTOS method. And the other result is that we found we can screen effective drugs for uterine carcinosarcoma by CTOS method and drug screening kit. We could not proceed to animal model. However we showed personalized medicine is also feasible by CTOS methods.

Free Research Field

婦人科腫瘍