Establishment of non-invasive cancer screening for endometrial cancer

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462595
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Okayama University
• Principal Investigator: Nakamura Keiichiro 岡山大学, 大学病院, 講師 (90359886)
• Co-Investigator(Kenkyū-buntansha): NAGASAKA TAKESHI 岡山大学, 大学病院, 講師 (30452569) ; UNEDA YUZOU 岡山大学, 大学病院, 助教 (10573735) ; SUNO MANABU 岡山大学, 医療教育統合開発センター, 准教授 (20621189) ; HIRAMATSU YUJI 岡山大学, 医歯薬学総合研究科, 教授 (80218817)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 子宮体癌 / LS / MSI / MMR

Outline of Final Research Achievements

We developed a new Lynch syndrome screening strategy for endometrial cancer by detection of 1)MSI using a panel of 4 mononucleotide microsatellite markers (BAT26, NR21, NR27, and CAT25)　2) protein expression for MLH1, MSH2, PMS2, MSH6 using immunohistochemical (IHC) staining, and 3) MLH1 promoter CpG island using PCR.

Free Research Field

婦人科