Role of androgen for metabolism in women during the menopausal transition

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462596
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: The University of Tokushima
• Principal Investigator: YASUI Toshiyuki 徳島大学, 大学院医歯薬学研究部, 教授 (40230205)
• Co-Investigator(Kenkyū-buntansha): MATSUI Sumika 徳島大学, 病院, 助教 (00622888) ; IRAHARA Minoru 徳島大学, 大学院医歯薬学研究部, 教授 (20160070)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 周閉経期 / 脂質代謝 / 糖代謝 / 男性ホルモン

Outline of Final Research Achievements

The role of androgen including testosterone and DHEA-S has not been clarified in women during the menopausal transition. Androgen such as free testosterone and bioavailable testosterone might be involved in changes in systolic blood pressure, diastolic blood pressure and circulating levels of triglyceride and HDL-C in women during the menopausal transition. Changes in adiponectin and leptin during the menopausal transition showed unique patterns, and testosterone was associated with these patterns of adiponectin and leptin. It has been suggested that decreases in DHEA-S levels in women who received oral and transdermal hormone replacement therapy for menopausal symptoms were involved in feedback mechanism of hypothalamus-pituitary-adrenal gland. Further studies for involvement of estrogen in hypothalamus-pituitary-adrenal with hypothalamus-pituitary-ovarian axis.

Free Research Field

生殖内分泌学