2015 Fiscal Year Final Research Report
Establishment of anti-tumor effector cells that cancel immune-suppressive status and application for immunotherapy for ovarian cancer
| Project/Area Number |
25462607
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Saitama Medical University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 卵巣がん / 免疫 |
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| Outline of Final Research Achievements |
The present study investigated the role of human iNKT cells in the regulation of dendritic cells (DCs) function. The activation of iNKT cells by their specific ligand alpha-galactosylceramide enhanced the IL-27 production by DCs. The up-regulation of IL-27 is associated with a production of IFN-gamma from iNKT cells. These findings indicate that iNKT cells modify the DC function to enhance the IL-27 that promotes the cell-mediated anti-tumor immune responses.
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| Free Research Field |
産婦人科学
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