2015 Fiscal Year Final Research Report
The origin of ovarian clear cell carcinoma and endometrioid carcinoma malignant transformation from endometriosis
| Project/Area Number |
25462611
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Keio University |
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Principal Investigator |
Akahane Tomoko 慶應義塾大学, 医学部, 特任助教 (40398699)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 卵巣癌 |
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| Outline of Final Research Achievements |
A recent study, ovarian cancer is not single character, carcinogenesis original cell and carcinogenesis mechanisms have been elucidated to be different by histopathological type. This study is to clarify the carcinogenic mechanism of ovarian cancer from endometriosis. Analyzed of gene mutation and protein expression in endometriosis co-existence clear cell carcinoma and endometrial cancer. TP53 gene mutations were similar to the characteristics of the serous cancer. These results may suggest that ovarian cancer of origin from endometriosis were mixed serous cancer of origin from fallopian tube epithelial cell.
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| Free Research Field |
婦人科腫瘍学
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