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2015 Fiscal Year Final Research Report

Alteration of tumor immunity and anti-cancer drug / hormone sensitivity in endometrial cancer with frequent MMR mechanism abnormality

Research Project

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Project/Area Number 25462612
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Obstetrics and gynecology
Research InstitutionKeio University

Principal Investigator

SUSUMU NOBUYUKI  慶應義塾大学, 医学部, 准教授 (90206459)

Research Collaborator YAMAGAMI Wataru  
NODA Tomomi  
SAKAI Kensuke  
MAKABE Takesi  
NINOMIYA Tomomi  
HIRASAWA Akira  
KATAOKA Fumio  
NOMURA Hiroyuki  
BANNO Kouji  
AOKI Daisuke  
Project Period (FY) 2013-04-01 – 2016-03-31
Keywords子宮内膜癌 / 腫瘍免疫 / 黄体ホルモン療法 / 化学療法 / MMR
Outline of Final Research Achievements

The MSI-positive tumors showed significantly higher grades and larger numbers of TILs than MSI-negative tumors. The COX-2-high group showed fewer TILs than COX-2-low group. Multivariate analysis identified a low number of TILs, positive lymph node involvement, and high tumor malignancy grade as factors independently associated with poor prognosis. The number of TILs, which was increased by MSI and decreased by COX-2 expression, was associated with a poorer prognosis in patients with endometrial cancer. We also propose that COX-2 may block MSI-activated TILs in the tumor microenvironment. Regarding fertility-preserving hormonal therapy, we performed hormonal therapy for 214 young patients with atypical endometrial hyperplasia or endometrioid adenocarcinoma G1. We succeeded in 83 pregnancies in 62 patients and showed 7.5% as the frequency of double cancer, and also revealed the safety and effectiveness of repeated MPA therapy after recurrence with the low incidence of double cancer.

Free Research Field

医歯薬学

URL: 

Published: 2017-05-10  

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