2015 Fiscal Year Final Research Report
Alteration of tumor immunity and anti-cancer drug / hormone sensitivity in endometrial cancer with frequent MMR mechanism abnormality
| Project/Area Number |
25462612
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Keio University |
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Principal Investigator |
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| Research Collaborator |
YAMAGAMI Wataru
NODA Tomomi
SAKAI Kensuke
MAKABE Takesi
NINOMIYA Tomomi
HIRASAWA Akira
KATAOKA Fumio
NOMURA Hiroyuki
BANNO Kouji
AOKI Daisuke
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 子宮内膜癌 / 腫瘍免疫 / 黄体ホルモン療法 / 化学療法 / MMR |
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| Outline of Final Research Achievements |
The MSI-positive tumors showed significantly higher grades and larger numbers of TILs than MSI-negative tumors. The COX-2-high group showed fewer TILs than COX-2-low group. Multivariate analysis identified a low number of TILs, positive lymph node involvement, and high tumor malignancy grade as factors independently associated with poor prognosis. The number of TILs, which was increased by MSI and decreased by COX-2 expression, was associated with a poorer prognosis in patients with endometrial cancer. We also propose that COX-2 may block MSI-activated TILs in the tumor microenvironment. Regarding fertility-preserving hormonal therapy, we performed hormonal therapy for 214 young patients with atypical endometrial hyperplasia or endometrioid adenocarcinoma G1. We succeeded in 83 pregnancies in 62 patients and showed 7.5% as the frequency of double cancer, and also revealed the safety and effectiveness of repeated MPA therapy after recurrence with the low incidence of double cancer.
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| Free Research Field |
医歯薬学
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