Investigation of cell characteristics of cancer metastasis and drug resistance using gynecological cancer's specific sugar chains.

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462623
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Sasaki Foundation
• Principal Investigator: SAKAMOTO Masaru 公益財団法人佐々木研究所, その他部局等, 研究員 (20260101)
• Co-Investigator(Renkei-kenkyūsha): KIKUCHI Ryoko 公益財団法人佐々木研究所, 附属研究所, 研究員 (80535063)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: レザフィリン / PDT / 子宮頸癌 / ガレクチン-4

Outline of Final Research Achievements

To take a photosensitizer more specifically in cancer at PDT (photodynamic therapy) of gynecological cancer by application of sugar chains and its binding molecules, lectins, we tried to identify the glycoproteins which participate in cancer specific uptake of the photosensitizer, laserphyrin. We compared laserphyrin uptake of the cell lines of cervical cancer with the uptake of immortalized cells from normal cervix uteri or normal fibroblasts, the uptakes were much the same. However, at an organizational level, tumors took laserphyrin more than non-tumor tissues. To identify the glycoproteins that involve in the cancer specific laserphyrin uptake, we have to make an analysis at tissue level. We also performed analysis of galectin-4, the molecule that participates in sugar binding.

Free Research Field

婦人科腫瘍学