2015 Fiscal Year Final Research Report
Oxidative stress and redox regulation - a brand new protein in an inner ear -
| Project/Area Number |
25462626
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Gunma University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | レドックス / 酸化ストレス / イノシトール3リン酸レセプター / 活性酸素 / dROM / BAP |
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| Outline of Final Research Achievements |
Oxidative stress is an imbalance between the production and the elimination of oxidant species. In cancer and infection, white blood cells overproduce reactive oxygen species, causing the oxidative stress. In the present study, we evaluated the oxidative stress in patients with cancer, and compared the relationship between the oxidative stress and the number of white blood cells (WBC). The diacron-reactive oxygen metabolite (dROM), which indicated the concentration of hydroperoxides in serum, was measured as an index of oxidative stress. The biological antioxidant potential (BAP), which indicated the concentration of deoxidized iron ion in serum, was also measured as an index of anti-oxidative status. We compared head and neck carcinoma patients (HNC) who were treated by chemotherapy and otitis media patients (OM) who had surgery. The dROM was significantly high in HNC, although dROM in OM was normal.
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| Free Research Field |
耳鼻咽喉科
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